Ngày đăng: 09/08/2022 05:27 AM
Scientists identify key mechanism controlling skin regeneration
August 3, 2022
The outer layer of skin, the epidermis, is constantly turning over to replace dead or damaged cells throughout our lifetime. Skin stem cells need to continuously make decisions: either make more copies of themselves (self-renewal) or switch their fate towards differentiation. The molecular mechanisms controlling this process remain poorly understood. Now a research team has identified a molecular switch that plays an early and critical role in the skin stem cell differentiation process.
Story Source: Materials provided by Northwestern University. Original written by Megan Fellman. Note: Content may be edited for style and length.
Journal Reference: Sarah M. Lloyd, Daniel B. Leon, Mari O. Brady, Deborah Rodriguez, Madison P. McReynolds, Junghun Kweon, Amy E. Neely, Laura A. Blumensaadt, Patric J. Ho, Xiaomin Bao. CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32098-2